The Santiago has roughly the same interior volume as the L300 and may even be a bit larger. As a former Santiago owner, I think I know what wlk is getting at. The 411 bass driver always struck me as underdamped with a somewhat bloated character. It definitely played lower than the similar 416 based Valencia. However, in my opinion it did not have anywhere near the same level of bass articulation and definition.
I have been told that porting the 411 does not work well due to the underdamped suspension, but I am not aware of anyone that tried it. Replacing the 411 with a 2235 would be an interesting experiment. They are very close in sensitivity such that the 801 cross-over could likely still be used. You would have to calculate the exact interior volume (making sure you subtract the fairly substantial horn/driver volume) and then design an appropriate tuning and port design. I would port it out the back just in case you decided you wanted to resell the system at some point with the original components. It would be cosmetically easier to fix in the back.